E. ALTINDIS

Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection

This study identifies GIV-VILP as a viral mimic of host insulin/IGF-1 that selectively activates the Akt/PI3K pathway during infection, enhancing viral replication.

The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset

This paper investigates how Parabacteroides distasonis colonization affects the microbiome, immune responses, and diabetes onset in NOD mice, finding it induces insulitis and activates specific T-cells without causing broad inflammation.

Children Who Develop Celiac Disease Exhibit Distinct Metabolic Pathways Among Their Gut Microbiota Years Before Diagnosis

A Gut Microbial Peptide and Molecular Mimicry in the Pathogenesis of Type 1 Diabetes

This paper identifies a gut microbial peptide that mimics an insulin epitope and contributes to Type 1 Diabetes pathogenesis by triggering immune cross-reactivity and accelerating disease onset in mice.

Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice

This study characterizes double-chain viral insulin-like peptides (dcVILPs) and shows they stimulate glucose uptake in white adipose tissue in mice with higher efficacy than insulin.

Dynamics of Gut Microbiome, IgA Response and Plasma Metabolome in Development of Pediatric Celiac Disease

This study identifies distinct gut microbiota, IgA responses, and plasma metabolite changes in children who develop celiac disease before diagnosis.