Author

R. H. Friedline

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

J. K. Kim· 4 shared E. Tsagkaraki· 2 shared F. Henriques· 2 shared M. Kelly· 2 shared M. P. Czech· 2 shared X. Hu· 2 shared Y. Shen· 2 shared A. Desai· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBioengineering

J. K. Kim

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

E. Tsagkaraki, S. Nicoloro, T. De Souza, J. Solivan-Rivera, A. Desai, Y. Shen, M. Kelly, A. Guilherme, F. Henriques, R. Ibraheim, N. Amrani, K. Luk, S. Maitland, R. H. Friedline, L. Tauer, , M. P. Czech

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

bioRxiv · Oct 13, 2020Bioengineering

Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice

M. Chrudinova, F. Moreau, H. L. Noh, T. Panikova, L. Zakova, R. H. Friedline, F. A. Valenzuela, J. K. Kim, J. Jiracek, C. R. Kahn, E. Altindis

This study characterizes double-chain viral insulin-like peptides (dcVILPs) and shows they stimulate glucose uptake in white adipose tissue in mice with higher efficacy than insulin.

bioRxiv · Aug 21, 2020Cell Biology

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

J. K. Corrigan, D. Ramachandran, Y. He, C. Palmer, M. J. Jurczak, B. Li, R. H. Friedline, J. K. Kim, J. J. Ramsey, L. Lantier, O. P. McGuinness, A. S. Banks, Mouse Metabolic Phenotyping Center Energy Balance Working Group

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

eLife · May 1, 2020Peer-reviewedPhysiology

CRISPR delivery particles for developing therapeutic strategies in metabolic disease

Y. Shen, J. L. Cohen, S. M. Nicoloro, M. Kelly, B. Yenilmez, F. Henriques, E. Tsagkaraki, Y. J. K. Edwards, X. Hu, R. H. Friedline, J. K. Kim, M. P. Czech

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

bioRxiv · Jun 21, 2018Bioengineering