Author

E. Bielecka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

T. Kantyka· 4 shared J. Potempa· 3 shared A. Lesner· 2 shared J. Koziel· 2 shared K. Falkowski· 2 shared M. Kalinska· 2 shared P. Grudnik· 2 shared A. Biela· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersMicrobiology

T. Kantyka

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Author profile →

4 papers

Recent·Most cited

Periodontopathogens interfere with the human renin-angiotensin system through a surface-attached protease

I. Waligorska, K. Zak, J. Budziaszek, E. Bielecka, T. Kantyka, J. Koziel, I. Thogersen, J. Enghild, P. Grudnik, J. Potempa, M. Ksiazek

This study shows that oral pathogens Porphyromonas gingivalis and Tannerella forsythia use surface-attached proteases to alter the renin-angiotensin system by generating Ang 1-7.

bioRxiv · Jun 20, 2024 · PreprintMicrobiology

Glycosaminoglycans act as activators of peptidylarginine deiminase 4

G. P. Bereta, E. Bielecka, K. Marzec, L. Pijanowski, A. Biela, P. Wilk, M. Kaminska, J. Nowak, E. Wator, P. Grudnik, D. Kowalczyk, J. Koziel, P. Mydel, M. Poreba, T. Kantyka

This study identifies glycosaminoglycans as activators of PAD4, showing they enhance Ca2+ affinity and induce NETosis, with implications for rheumatoid arthritis.

bioRxiv · Jun 17, 2024 · PreprintBiochemistry

Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx library-based analysis

K. Falkowski, E. Bielecka, I. B. Thogersen, O. Bochenska, K. Płaza, M. Kalinska, L. Sasiadek, M. Magoch, A. Pecak, M. Wisniewska, N. Gruba, M. Wysocka, A. Wojtysiak, M. Brzezinska-Bodal, K. Sychowska, , T. Kantyka

This study identifies KLK14 as a specific activator of proMT-MMPs using a CleavEx library-based approach, revealing its role in ECM remodeling and potential implications in cancer.

bioRxiv · Apr 23, 2020Biochemistry

Kallikrein 13: a new player in coronaviral infections.

A. Milewska, K. Falkowski, M. Kalinska, E. Bielecka, A. Naskalska, P. Mak, A. Lesner, M. Ochman, M. Urlik, J. Potempa, T. Kantyka, K. Pyrc

This study identifies KLK13 as a protease required for HCoV-HKU1 infection and shows it cleaves the viral S protein, determining tissue specificity and potential interspecies transmission.

bioRxiv · Mar 1, 2020 · PreprintMicrobiology