Glycosaminoglycans act as activators of peptidylarginine deiminase 4
G. P. Bereta, E. Bielecka, K. Marzec, L. Pijanowski, A. Biela, P. Wilk, M. Kaminska, J. Nowak, E. Wator, P. Grudnik, D. Kowalczyk, J. Koziel, P. Mydel, M. Poreba, T. Kantyka
This study identifies glycosaminoglycans as activators of PAD4, showing they enhance Ca2+ affinity and induce NETosis, with implications for rheumatoid arthritis.
bioRxiv · Jun 17, 2024 · PreprintBiochemistry