Author

E. Frickel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. Clough· 2 shared D. Fisch· 2 shared N. Yoshida· 2 shared A. Beling· 1 shared A. Borg· 1 shared A. G. van der Veen· 1 shared A. Napolitano· 1 shared A. Piro· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

B. Clough

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

p97/VCP targets Toxoplasma gondii vacuoles for parasite restriction in interferon-stimulated human cells

B. Clough, D. Fisch, T. H. Mize, V. Encheva, A. Snijders, E. Frickel

This study identifies p97/VCP as an IFN-gamma-dependent host factor that restricts Toxoplasma gondii by acidifying the parasitophorous vacuole in multiple human cell types.

bioRxiv · Jun 20, 2023 · PreprintImmunology

Toxoplasma-proximal and distal control by GBPs in human macrophages

D. Fisch, B. Clough, R. T. Khan, L. Healy, E. Frickel

This study identifies GBP1, 2, and 5 roles in controlling Toxoplasma gondii infection in human macrophages, with GBP1 acting proximally and GBP2/5 distally.

bioRxiv · Aug 24, 2021Microbiology

In vivo control of Toxoplasma gondii by zebrafish macrophages

N. Yoshida, M.-C. Domart, A. Yakimovich, M. J. Mazon-Moya, L. Collinson, J. Mercer, E. Frickel, S. Mostowy

This study uses a zebrafish model to show that macrophages control Toxoplasma gondii infection in vivo, with type II and III strains having higher infectious burdens than type I.

bioRxiv · Nov 2, 2019 · PreprintMicrobiology

TCR-MHC Interaction Strength Defines Trafficking and Resident Memory Status of CD8 T cells in the Brain

A. Sanecka, N. Yoshida, E. M. Kolawole, H. Patel, B. D. Evavold, E. Frickel

This study shows that TCR-MHC interaction strength determines the trafficking and resident memory status of CD8 T cells in the brain during chronic Toxoplasma gondii infection.

bioRxiv · Feb 9, 2018Immunology

Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility

A. Piro, D. Hernandez, S. Luoma, E. Feeley, R. Finethy, A. Yirga, E. Frickel, C. Lesser, J. Coers

This paper shows human GBP1 uniquely captures cytosolic Gram-negative bacteria via a C-terminal triple-arginine motif, inhibiting their actin-based motility and cell-to-cell spread, while Shigella uses IpaH9.8 to resist GBP1 targeting.

bioRxiv · Nov 1, 2017Microbiology

Free ISG15 as a dimer generates IL-1β-producing CD8α+ dendritic cells at the site of infection

A. Napolitano, A. G. van der Veen, M. Bunyan, A. Borg, S. Kjaer, A. Beling, K.-P. Knobeloch, E. Frickel

The paper shows free ISG15 dimers enhance IL-1β production by CD8+ dendritic cells during Toxoplasma infection, linking ISG15 to cytokine responses.

bioRxiv · Feb 27, 2017Immunology