N. Yoshida

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

Binding of cardiolipin to the KcsA channel at the membrane outer leaflet allosterically opens the inner gate

The paper shows cardiolipin binding to KcsA's outer leaflet triggers an allosteric opening of the inner gate via interactions with Arg64 and Arg89.

NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression

This study shows that NKG2D signaling promotes IL-17A-producing γδT cells, which drive cancer progression in intestinal tumors.

Satelight: Self-Attention-Based Model for Epileptic Spike Detection from Multi-Electrode EEG

Satelight detects epileptic spikes in EEG using self-attention, achieving high accuracy with fewer parameters than existing models.

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

This study shows that TLR7 activation by accumulated nucleosides in lysosomes drives histiocytosis in SLC29A3 disorders.

In vivo control of Toxoplasma gondii by zebrafish macrophages

This study uses a zebrafish model to show that macrophages control Toxoplasma gondii infection in vivo, with type II and III strains having higher infectious burdens than type I.

Molecular mechanism of depolarization-dependent inactivation in W366F mutant of Kv1.2

The paper investigates the molecular mechanism of C-type inactivation in a Kv1.2 mutant using molecular dynamics simulations and 3D-RISM analysis.

TCR-MHC Interaction Strength Defines Trafficking and Resident Memory Status of CD8 T cells in the Brain

This study shows that TCR-MHC interaction strength determines the trafficking and resident memory status of CD8 T cells in the brain during chronic Toxoplasma gondii infection.