Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy
M. M. Olcina, S. Melemenidis, D. K. Nambiar, R. K. Kim, K. M. Casey, R. von Eyben, T. M. Woodruff, E. G. Graves, Q.-T. Le, M. Stucki, A. J. Giaccia
This study shows that targeting C5aR1 with PMX205 improves tumor radiation response and reduces normal tissue toxicity in mice.
bioRxiv · Oct 27, 2020 · PreprintCancer Biology