Author

M. Stucki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. J. Giaccia· 2 shared D. Durocher· 2 shared D. K. Nambiar· 2 shared M. De Marco Zompit· 2 shared M. M. Olcina· 2 shared Q.-T. Le· 2 shared R. K. Kim· 2 shared S. Adam· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

A. J. Giaccia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

C. Beach, D. MacLean, D. Majorova, S. Melemenidis, D. K. Nambiar, R. K. Kim, G. N. Valbuena, S. Guglietta, C. Krieg, M. D. Damavandi, T. Suwa, A. Easton, E. Domingo, E. J. Moon, D. Jiang, , M. M. Olcina

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

M. De Marco Zompit, C. Mooser, S. Adam, S. E. Rossi, A. Jeanrenaud, P.-A. Leimbacher, D. Fink, D. Durocher, M. Stucki

This study identifies CIP2A as a mitosis-specific protein that forms a complex with TOPBP1 to regulate DSB repair and chromosomal stability during mitosis.

bioRxiv · Feb 8, 2021Cell Biology

CIP2A is a prime synthetic-lethal target for BRCA-mutated cancers

S. Adam, S. E. Rossi, N. Moatti, M. De Marco Zompit, T. F. Ng, A. Alvarez-Quilon, J. Desjardins, V. Bhaskaran, G. Martino, D. Setiaputra, S. M. Noordermeer, T. K. Ohsumi, N. Hustedt, R. K. Szilard, N. Chaudhary, , D. Durocher

The paper identifies CIP2A as a synthetic-lethal target in BRCA-mutated cancers by showing its essential role in mitotic chromosome stability and its interaction with TOPBP1.

bioRxiv · Feb 8, 2021 · PreprintCancer Biology

Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy

M. M. Olcina, S. Melemenidis, D. K. Nambiar, R. K. Kim, K. M. Casey, R. von Eyben, T. M. Woodruff, E. G. Graves, Q.-T. Le, M. Stucki, A. J. Giaccia

This study shows that targeting C5aR1 with PMX205 improves tumor radiation response and reduces normal tissue toxicity in mice.

bioRxiv · Oct 27, 2020 · PreprintCancer Biology