Author

S. Melemenidis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. J. Giaccia· 2 shared D. K. Nambiar· 2 shared M. M. Olcina· 2 shared M. Stucki· 2 shared Q.-T. Le· 2 shared R. K. Kim· 2 shared T. M. Woodruff· 2 shared A. C. Koong· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. J. Giaccia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints

O. G. G. Drayson, S. Melemenidis, N. Katila, V. Viswanathan, E. Kramar, R. Zhang, R. Kim, N. Ru, B. Petit, S. Dutt, R. Manjappa, R. Ashraf, B. C. Lau, L. Soto, L. Skinner, , C. Limoli

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

bioRxiv · Jan 25, 2024Cancer Biology

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

C. Beach, D. MacLean, D. Majorova, S. Melemenidis, D. K. Nambiar, R. K. Kim, G. N. Valbuena, S. Guglietta, C. Krieg, M. D. Damavandi, T. Suwa, A. Easton, E. Domingo, E. J. Moon, D. Jiang, , M. M. Olcina

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension

S. Taylor, K. Contrepois, B. Benayoun, L. A. Jiang, S. Isobe, L. Wang, S. Melemenidis, M. O. Ozen, S. Otsuki, T. Shinohara, A. J. Sweatt, J. Kaplan, A. Cao, J.-R. Moonen, D. P. Marciano, , M. Rabinovitch

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

bioRxiv · Jan 8, 2021Immunology

Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy

M. M. Olcina, S. Melemenidis, D. K. Nambiar, R. K. Kim, K. M. Casey, R. von Eyben, T. M. Woodruff, E. G. Graves, Q.-T. Le, M. Stucki, A. J. Giaccia

This study shows that targeting C5aR1 with PMX205 improves tumor radiation response and reduces normal tissue toxicity in mice.

bioRxiv · Oct 27, 2020 · PreprintCancer Biology