Author

Q.-T. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. J. Giaccia· 2 shared D. K. Nambiar· 2 shared M. M. Olcina· 2 shared M. Stucki· 2 shared R. K. Kim· 2 shared S. Melemenidis· 2 shared T. M. Woodruff· 2 shared A. C. Koong· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. J. Giaccia

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Author profile →

3 papers

Recent·Most cited

Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC

N. Wamsley, E. Wilkerson, L. Guan, K. LaPak, T. Schrank, B. Holmes, R. Sprung, P. E. Gilmore, S. Gerndt, R. Jackson, R. Paniello, P. Pipkorn, S. V. Puram, J. Rich, R. R. Townsend, , M. B. Major

This paper develops a targeted proteomics assay to quantify NRF2 pathway components and clinical biomarkers in HNSCC, identifying correlations between NRF2 activity, HPV infection, and immune markers.

bioRxiv · Mar 13, 2023Cancer Biology

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

C. Beach, D. MacLean, D. Majorova, S. Melemenidis, D. K. Nambiar, R. K. Kim, G. N. Valbuena, S. Guglietta, C. Krieg, M. D. Damavandi, T. Suwa, A. Easton, E. Domingo, E. J. Moon, D. Jiang, , M. M. Olcina

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy

M. M. Olcina, S. Melemenidis, D. K. Nambiar, R. K. Kim, K. M. Casey, R. von Eyben, T. M. Woodruff, E. G. Graves, Q.-T. Le, M. Stucki, A. J. Giaccia

This study shows that targeting C5aR1 with PMX205 improves tumor radiation response and reduces normal tissue toxicity in mice.

bioRxiv · Oct 27, 2020 · PreprintCancer Biology