Author

S. Humphrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Kerr· 2 shared C. Dive· 2 shared D. M. Wall· 2 shared F. Blackhall· 2 shared K. L. Simpson· 2 shared K. Thummler· 2 shared M. Carter· 2 shared M. Galvin· 2 shared

Activity by Year

2016-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

A. Kerr

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Characterisation of prophages in Clostridium clostridioforme: an understudied component of the intestinal microbiome

S. Humphrey, A. Marouli, K. Thummler, M. Mullin, D. M. Wall

This study characterizes prophages in Clostridium clostridioforme LM41, identifying 15 prophages and their potential roles in host fitness and genetic diversity.

bioRxiv · Feb 29, 2024 · PreprintMicrobiology

Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer

A. Catozzi, M. Peiris-Pages, S. Humphrey, M. Revill, D. Morgan, J. Roebuck, Y. Chen, B. Davies-Williams, A. Lallo, M. Galvin, S. P. Pearce, A. Kerr, L. Priest, V. Foy, M. Carter, , K. L. Simpson

The paper identifies ATOH1 as a pro-metastatic oncogenic driver in SCLC by showing its role in cell survival and metastasis suppression upon depletion.

bioRxiv · Feb 16, 2024 · PreprintCancer Biology

Genomic diversity of novel strains of mammalian gut microbiome derived Clostridium XIVa strains is driven by mobile genetic element acquisition

M. Kamat, M. J. Ormsby, S. Humphrey, S. K. Dixit, K. Thummler, C. Lapsley, K. Crouch, C. Jukes, H. Hulme, R. Burchmore, L. Meikle, L. Pritchard, D. M. Wall

The paper isolates and characterizes novel Clostridium XIVa strains from the murine gut, revealing genomic diversity driven by mobile genetic element acquisition and expanded biosynthetic potential.

bioRxiv · Jan 22, 2024 · PreprintMicrobiology

Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry

S. M. Pearsall, S. C. Williamson, F. J. Garcia Marques, S. Humphrey, E. Hughes, Y. T. Shue, A. Bermudez, K. Frese, M. Galvin, M. Carter, L. Preist, A. Kerr, C. Zhou, T. G. Oliver, J. D. Humphries, , C. Dive

This study identifies VM-competent non-neuroendocrine cells in SCLC that support vessel formation and tumor growth through integrin β1-dependent ECM remodeling.

Journal of Thoracic Oncology · Oct 1, 2023Peer-reviewedCancer Biology

The secret life (cycle) of temperate bacteriophages

A. Fillol-Salom, R. Bacigalupe, S. Humphrey, Y. N. Chiang, J. Chen, J. Penades

The paper challenges the universal ERP model of temperate phage life cycles by showing wildtype P22 follows an RPE program, optimizing gene transfer for host evolution.

bioRxiv · Aug 25, 2021 · PreprintMicrobiology

Genome-Wide Fitness Analyses of the Foodborne Pathogen Campylobacter jejuni in In Vitro and In Vivo Models

S. de Vries, S. Gupta, A. Baig, E. Wright, A. Wedley, A. Nygaard Jensen, L. LaCharme Lora, S. Humphrey, H. Skovgard, K. Macleod, E. Pont, D. Wolanska, J. L'Heureux, F. Mobegi, D. Smith, , A. Grant

This study identifies genes essential for Campylobacter jejuni growth and survival across multiple in vitro and in vivo conditions using transposon sequencing.

bioRxiv · Nov 5, 2016Microbiology