Author

E. K. O'Shea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:imaging· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Gutu· 1 shared A. M. Darnell· 1 shared A. R. Subramaniam· 1 shared C. Y. Park· 1 shared D. M. Sabatini· 1 shared F. Chang· 1 shared G. A. Wyant· 1 shared J. S. Weissman· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCell Biology

A. Gutu

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3 papers

Recent·Most cited

Translational control through differential ribosome pausing during amino acid limitation in mammalian cells

A. M. Darnell, A. R. Subramaniam, E. K. O'Shea

The paper shows that amino acid limitation affects translation via codon-specific ribosome pausing, with arginine limitation causing pausing and leucine limitation preventing it through mTORC1/GCN2 signaling.

bioRxiv · May 14, 2018Cell Biology

Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

E. K. O'Shea, Z. Yu, L. E. Surface, C. Y. Park, M. A. Horlbeck, G. A. Wyant, M. Abu-Remaileh, T. R. Peterson, D. M. Sabatini, J. S. Weissman

The paper identifies SLC37A3 as a transporter required for nitrogen-containing bisphosphonates (N-BPs) to enter the cytosol, revealing their mechanism of action.

bioRxiv · Mar 27, 2018Biochemistry

Dynamical localization of a thylakoid membrane binding protein is required for acquisition of photosynthetic competency

A. Gutu, F. Chang, E. K. O'Shea

The paper shows that dynamic localization of Vipp1 at high curvature thylakoid regions is necessary for photosynthetic competency acquisition during the dark-to-light transition.

bioRxiv · Oct 8, 2017Cell Biology