Author

A. M. Darnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2

Frequent Co-Authors

M. G. Vander Heiden· 4 shared A. N. Lau· 2 shared B. T. Do· 2 shared C. A. Lewis· 2 shared C. Chidley· 2 shared E. C. Lien· 2 shared K. L. Abbott· 2 shared L. V. Danai· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

M. G. Vander Heiden

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

C. Chidley, A. M. Darnell, B. L. Gaudio, E. C. Lien, A. M. Barbeau, M. G. Vander Heiden, P. K. Sorger

This study uses a CRISPRi/a screening platform to identify nutrient transporters critical for cancer cell proliferation in diverse microenvironments and reveals their functional roles.

bioRxiv · Jan 26, 2023Cancer Biology

Cancer tissue of origin constrains the growth and metabolism of metastases

S. Sivanand, Y. Gultekin, P. Winter, S. Y. Vermeulen, K. Tchourine, K. L. Abbott, L. V. Danai, F. Gourgue, B. T. Do, K. Crowder, T. Kunchok, A. N. Lau, A. M. Darnell, A. Jefferson, S. Morita, , M. G. Vander Heiden

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

bioRxiv · Aug 17, 2022Cancer Biology

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

bioRxiv · Aug 16, 2022Cancer Biology

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

M. R. Sullivan, A. M. Darnell, M. F. Reilly, C. A. Lewis, M. G. Vander Heiden

This study shows methionine synthase is essential for cancer cell proliferation under physiological folate conditions but not in standard cell culture.

bioRxiv · Jun 12, 2020 · PreprintCancer Biology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology

Translational control through differential ribosome pausing during amino acid limitation in mammalian cells

A. M. Darnell, A. R. Subramaniam, E. K. O'Shea

The paper shows that amino acid limitation affects translation via codon-specific ribosome pausing, with arginine limitation causing pausing and leucine limitation preventing it through mTORC1/GCN2 signaling.

bioRxiv · May 14, 2018Cell Biology