E. F. Koslover

Spatiotemporal Modeling of Mitochondrial Network Architecture

This study models mitochondrial network dynamics using simulations and analytic models to show how local parameters control network morphology and remodeling rates.

Luminal transport rates through intact endoplasmic reticulum limit the magnitude of localized Ca2+ signals

The paper shows that ER shape affects Ca2+ release efficiency through transport limitations and buffer protein mobility.

Dendrite architecture determines mitochondrial distribution patterns in vivo

The paper shows that mitochondrial distribution in Drosophila dendrites follows scaling rules based on dendrite morphology, independent of neuronal activity.

Spatiotemporal analysis of axonal autophagosome-lysosome dynamics reveals limited fusion events trigger two-step maturation

The paper uses a quantitative model to analyze axonal autophagosome-lysosome dynamics, revealing limited fusion events and a two-step maturation process.

Mitochondrial mRNA localization is governed by translation kinetics and spatial transport

The paper develops a model to explain how mitochondrial mRNA localization in yeast depends on translation kinetics and spatial transport, finding that metabolic state influences localization through changes in these factors.

Optimizing Mitochondrial Maintenance in Extended Neuronal Projections

This study develops mathematical models to analyze mitochondrial maintenance strategies in neurons, finding that infrequent exchange and selective recycling optimize mitochondrial health.

Hitching a Ride: Mechanics of Organelle Transport Through Linker-Mediated Hitchhiking

The paper develops a quantitative model to study hitchhiking transport of organelles in fungal hyphae, showing how linker proteins and cytoskeletal tracks affect transport efficiency.

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

The paper maps nucleosome barriers' topography and Pol II dynamics using single-molecule assays and reveals how H2A.Z and uH2B modify barrier height and width, affecting transcription.

Spatial Control of Neuronal Metabolism Through Glucose-Mediated Mitochondrial Transport Regulation

The paper quantitatively models how glucose-mediated mitochondrial transport regulation affects spatial organization and metabolism in neurons.

Listeria monocytogenes cell-to-cell spread in epithelia is heterogeneous and dominated by rare pioneer bacteria

This study shows that L. monocytogenes spreads heterogeneously in epithelial cells, with rare pioneer bacteria driving infection spread and persistence.