Author

E. M. Leaf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. Treichel· 4 shared D. Veesler· 4 shared N. P. King· 4 shared C. Stewart· 3 shared J. Lee· 3 shared A. C. Walls· 2 shared A. Schaefer· 2 shared A. Valdez· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersImmunology

C. Treichel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Computationally designed mRNA-launched protein nanoparticle vaccines

G. G. Hendricks, L. Grigoryan, M. J. Navarro, N. J. Catanzaro, M. L. Hubbard, J. M. Powers, M. Mattocks, C. Treichel, A. C. Walls, J. Lee, D. Ellis, J. Y. Wang, S. Cheng, M. C. Miranda, A. Valdez, , N. P. King

This paper develops an mRNA-launched nanoparticle vaccine that combines protein nanoparticle and mRNA vaccine advantages, showing enhanced antibody and T cell responses in mice.

bioRxiv · Jul 22, 2024Immunology

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

C. W. Chao, K. R. Sprouse, M. C. Miranda, N. J. Catanzaro, M. L. Hubbard, A. Addetia, C. Stewart, J. T. Brown, A. Dosey, A. Valdez, R. Ravichandran, G. G. Hendricks, M. Ahlrichs, C. Dobbins, A. Hand, , N. P. King

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

bioRxiv · Mar 13, 2024Immunology

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines

J. Lee, C. Stewart, A. Schaefer, E. M. Leaf, Y.-J. Park, D. Asarnow, J. M. Powers, C. Treichel, D. Corti, R. Baric, N. P. King, D. Veesler

This paper develops a stabilization strategy for sarbecovirus fusion machinery vaccines, showing broad reactivity and protection against SARS-CoV-2 variants.

bioRxiv · Dec 12, 2023Biochemistry

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

J. Lee, S. Zepeda, Y.-J. Park, A. L. Taylor, J. Quispe, C. Stewart, E. M. Leaf, C. Treichel, D. Corti, N. P. King, T. N. Starr, D. Veesler

This study characterizes the receptor tropism and antigenicity of a clade 3 sarbecovirus, identifying broad ACE2 usage and cross-neutralizing antibodies with implications for vaccine design.

bioRxiv · Sep 12, 2023Biochemistry