Author

J. T. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. Veesler· 3 shared K. R. Sprouse· 2 shared A. Addetia· 1 shared A. Balmeli· 1 shared A. C. Walls· 1 shared A. Dosey· 1 shared A. Hand· 1 shared A. J. Haraczy· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersEvolutionary Biology

D. Veesler

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Author profile →

4 papers

Recent·Most cited

Functional and antigenic landscape of the Nipah virus receptor binding protein

B. B. Larsen, T. McMahon, J. T. Brown, Z. Wang, C. E. Radford, J. E. Crowe, D. Veesler, J. D. Bloom

This study uses deep mutational scanning to analyze how mutations in the Nipah virus receptor-binding protein affect function, receptor binding, and antibody escape, revealing constrained regions and limited antigenic variation in natural strains.

Cell · May 1, 2025Peer-reviewedEvolutionary Biology

Broadly neutralizing antibodies against emerging delta-coronaviruses

M. Rexhepaj, Y.-J. Park, L. Perruzza, D. Asarnow, M. McCallum, K. Culap, C. Saliba, G. Leoni, A. Balmeli, C. Yoshiyama, M. S. Dickinson, J. Quispe, J. T. Brown, M. A. Tortorici, K. R. Sprouse, , D. Veesler

The paper isolates two human monoclonal antibodies that broadly neutralize PDCoV variants and identifies their mechanism of action.

bioRxiv · Mar 27, 2024 · PreprintBiochemistry

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

C. W. Chao, K. R. Sprouse, M. C. Miranda, N. J. Catanzaro, M. L. Hubbard, A. Addetia, C. Stewart, J. T. Brown, A. Dosey, A. Valdez, R. Ravichandran, G. G. Hendricks, M. Ahlrichs, C. Dobbins, A. Hand, , N. P. King

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

bioRxiv · Mar 13, 2024Immunology

Characterization of nuclear pore complex targeting domains in Pom152 in Saccharomyces cerevisiae

J. T. Brown, A. J. Haraczy, C. M. Wilhelm, K. D. Belanger

This study identifies the minimal region of Pom152 required for nuclear pore complex localization in yeast and shows that other domains may affect its targeting or NPC affinity.

bioRxiv · Jun 18, 2020Cell Biology