Author

S. Zepeda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

D. Veesler· 3 shared A. C. Walls· 2 shared A. De Marco· 2 shared A. Telenti· 2 shared B. Guarino· 2 shared C. Silacci Fregni· 2 shared D. Corti· 2 shared D. Pinto· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

D. Veesler

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

J. Lee, S. Zepeda, Y.-J. Park, A. L. Taylor, J. Quispe, C. Stewart, E. M. Leaf, C. Treichel, D. Corti, N. P. King, T. N. Starr, D. Veesler

This study characterizes the receptor tropism and antigenicity of a clade 3 sarbecovirus, identifying broad ACE2 usage and cross-neutralizing antibodies with implications for vaccine design.

bioRxiv · Sep 12, 2023Biochemistry

Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps

A. Muenks, S. Zepeda, G. Zhou, D. Veesler, F. DiMaio

This paper develops a tool to automatically determine ligand structures from cryoEM maps and evaluates its accuracy across EMDB data.

bioRxiv · Aug 16, 2022Biochemistry

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

B. Meng, I. Ferreira, A. Abdullahi, N. Goonawardane, A. Saito, I. Kimura, D. Yamasoba, S. A. Kemp, G. Papa, S. Fatihi, S. Rathore, P. Perera Gerba, T. Ikeda, M. Toyoda, T. S. Tan, , S. Zepeda

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

bioRxiv · Dec 17, 2021Microbiology

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody

M. A. Tortorici, N. Czudnochowski, T. N. Starr, R. Marzi, A. C. Walls, F. Zatta, J. E. Bowen, S. Jaconi, J. di Iulio, Z. Wang, A. De Marco, S. Zepeda, D. Pinto, Z. Liu, M. Beltramello, , J. Bloom

This paper identifies a human monoclonal antibody that broadly neutralizes SARS-CoV-2 variants and zoonotic sarbecoviruses by targeting a conserved epitope on the spike protein.

bioRxiv · Apr 7, 2021 · PreprintImmunology

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

M. McCallum, A. De Marco, F. Lempp, M. A. Tortorici, D. Pinto, A. C. Walls, M. Beltramello, A. Chen, Z. Liu, F. Zatta, S. Zepeda, J. di Iulio, J. E. Bowen, M. Montiel-Ruiz, J. Zhou, , D. Veesler

The paper identifies a conserved antigenic supersite on the SARS-CoV-2 N-terminal domain recognized by neutralizing antibodies and shows its vulnerability to mutations in variants.

bioRxiv · Jan 14, 2021Immunology