Author

E. Martinez-Perez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:C. elegans· 4 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

C. Barroso· 4 shared A. L. Jaso-Tamame· 2 shared G. Sioutas· 2 shared M. Castellano-Pozo· 2 shared S. Pacheco· 2 shared A. Castaner· 1 shared A. Kaczmarczyk· 1 shared A. Sato-Carlton· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersCell Biology

C. Barroso

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The kleisin subunit controls the function of meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

M. Castellano-Pozo, G. Sioutas, C. Barroso, P. Lopez-Jimenez, A. L. Jaso-Tamame, O. Crawley, N. Shao, J. Page, E. Martinez-Perez

This study shows that kleisin subunits determine the function of meiotic cohesins by controlling DNA binding modes and regulation by SCC-2 and WAPL-1.

bioRxiv · Oct 12, 2022Cell Biology

GRAS-1 is a conserved novel regulator of early meiotic chromosome dynamics in C. elegans

M. Martinez-Garcia, P. Robles, M. W. Skinner, K. A. Baran, S. Nadarajan, N. Shin, C. G. Silva-Garcia, T. T. Saito, S. Beese-Sims, A. Castaner, S. Pacheco, E. Martinez-Perez, P. W. Jordan, M. P. Colaiacovo

This study identifies GRAS-1 as a conserved regulator of early meiotic chromosome dynamics in C. elegans, showing its role in coordinating chromosome movement with cytoskeletal forces.

bioRxiv · Sep 6, 2022 · PreprintCell Biology

Cohesin is required for meiotic spindle assembly independent of its role in cohesion in C. elegans

K. P. McNally, B. M. Danlasky, C. Barroso, T. Gong, W. Li, E. Martinez-Perez, F. J. McNally

The paper shows cohesin is essential for meiotic spindle assembly in C. elegans without requiring its role in sister chromatid cohesion.

bioRxiv · Mar 10, 2022Cell Biology

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

O. Belan, C. Barroso, A. Kaczmarczyk, R. Anand, S. Federico, N. O'Reilly, M. D. Newton, E. Maeots, R. I. Enchev, E. Martinez-Perez, D. S. Rueda, S. J. Boulton

The paper uses single-molecule imaging to show how BRC-2 and RFS-1/RIP-1 mediate RAD-51 filament nucleation and growth during homologous recombination.

bioRxiv · Nov 5, 2020Biophysics

Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in C. elegans

A. Sato-Carlton, C. Nakamura-Tabuchi, X. Li, H. Boog, M. K. Lehmer, S. C. Rosenberg, C. Barroso, E. Martinez-Perez, K. D. Corbett, P. M. Carlton

This study shows that phosphorylation of HIM-3, a HORMA domain protein, regulates asymmetric synaptonemal complex disassembly in C. elegans meiosis by modulating its interaction with HTP-1 and HTP-2.

bioRxiv · Jul 1, 2020Cell Biology

Reactivation of chromosome signalling induces reversal of the meiotic program

M. Castellano-Pozo, S. Pacheco, G. Sioutas, A. L. Jaso-Tamame, M. H. Dore, E. Martinez-Perez

The paper shows that meiotic progression can be reversed by reactivating chromosome signaling, which re-installs DSB formation and chromosome movement machinery through CHK-2 activity.

bioRxiv · Sep 3, 2019 · PreprintCell Biology

Co-mutation and exclusion analysis in human tumors, a means for cancer biology studies and treatment design

S. Ochoa, E. Martinez-Perez, D. J. Zea, M. A. Molina-Vila, C. Marino-Buslje

The paper systematically analyzes co-mutations and exclusions across all cancer types, identifying driver loci and their interactions to inform cancer biology and treatment.

bioRxiv · Aug 30, 2017Cancer Biology