Author

S. J. Boulton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Cerutti· 1 shared A. Cicconi· 1 shared A. Galbiati· 1 shared A. Kaczmarczyk· 1 shared A. Sabantsev· 1 shared C. Barroso· 1 shared D. Dimakou· 1 shared D. Ebner· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

A. Cerutti

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

G. Rodriguez-Berriguete, M. Ranzani, R. Prevo, R. Puliyadi, N. Machado, H. R. Bolland, V. Millar, D. Ebner, M. Boursier, A. Cerutti, A. Cicconi, A. Galbiati, D. Grande, V. Grinkevich, J. Majithiya, , G. S. Higgins

This study shows that Polθ inhibitors ART558 and ART899 radiosensitize tumor cells without affecting normal fibroblasts, suggesting potential for safe cancer radiotherapy.

bioRxiv · Sep 27, 2022Cancer Biology

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

L. Bacic, G. Gaullier, A. Sabantsev, L. Lehmann, K. Brackmann, D. Dimakou, M. Halic, G. Hewitt, S. J. Boulton, S. Deindl

This study determines the structure of ALC1 bound to a PARylated nucleosome using cryo-EM, revealing intermediate states and functional roles in nucleosome remodeling.

bioRxiv · Jun 18, 2021Biophysics

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

O. Belan, C. Barroso, A. Kaczmarczyk, R. Anand, S. Federico, N. O'Reilly, M. D. Newton, E. Maeots, R. I. Enchev, E. Martinez-Perez, D. S. Rueda, S. J. Boulton

The paper uses single-molecule imaging to show how BRC-2 and RFS-1/RIP-1 mediate RAD-51 filament nucleation and growth during homologous recombination.

bioRxiv · Nov 5, 2020Biophysics