Author

E. Mukhaleva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

N. Vaidehi· 3 shared N. Ma· 2 shared A. S. RODIN· 1 shared A. Smrcka· 1 shared C. W. Dessauer· 1 shared F. R. Sadler· 1 shared G. Gogoshin· 1 shared N. R. Chandan· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

N. Vaidehi

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3 papers

Recent·Most cited

Cellular Lipids Regulate the Conformational Ensembles of the Disordered Intracellular Loop 3 in beta-2 Adrenergic Receptor

E. Mukhaleva, T. Yang, F. R. Sadler, S. Sivaramakrishnan, N. Ma, N. Vaidehi

This study shows that lipids like PIP2 and GM3 modulate the conformation of ICL3 in beta-2AR, affecting G protein coupling through membrane tilting and allosteric effects.

bioRxiv · Nov 28, 2023Biophysics

Bayesian network models identify co-operative GPCR:G protein interactions that contribute to G protein coupling

E. Mukhaleva, N. Ma, W. J. C. Van Der Velden, G. Gogoshin, S. Branciamore, S. Bhattacharya, A. S. RODIN, N. Vaidehi

This study uses Bayesian network modeling to identify cooperative GPCR:G protein interactions and their allosteric effects, revealing subnetworks that contribute to G protein coupling selectivity.

bioRxiv · Oct 9, 2023Biophysics

Stablization of Interdomain Interactions in G protein αi Subunits Determines Gαi Subtype Signaling Specificity

T. Lefevre, W. Wei, E. Mukhaleva, S. P. M. Venkata, N. R. Chandan, S. Abraham, Y. Li, C. W. Dessauer, N. Vaidehi, A. Smrcka

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.

bioRxiv · Mar 10, 2023Pharmacology & Toxicology