Author

N. R. Chandan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Abraham· 2 shared A. Smrcka· 1 shared A. V. Smrcka· 1 shared C. A. Parent· 1 shared C. W. Dessauer· 1 shared E. Mukhaleva· 1 shared N. Vaidehi· 1 shared S. P. M. Venkata· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

S. Abraham

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2 papers

Recent·Most cited

Stablization of Interdomain Interactions in G protein αi Subunits Determines Gαi Subtype Signaling Specificity

T. Lefevre, W. Wei, E. Mukhaleva, S. P. M. Venkata, N. R. Chandan, S. Abraham, Y. Li, C. W. Dessauer, N. Vaidehi, A. Smrcka

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.

bioRxiv · Mar 10, 2023Pharmacology & Toxicology

Identification of G Protein αi Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF

N. R. Chandan, S. Abraham, S. SenGupta, C. A. Parent, A. V. Smrcka

The paper identifies G protein αi signaling partners using proximity labeling, revealing a network including PDZ-RhoGEF and functional differences among Gi isoforms.

bioRxiv · Jul 15, 2021Pharmacology & Toxicology