Author

A. Smrcka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

W. Wei· 2 shared A. Anantharam· 1 shared A. Rabino· 1 shared B. L. Coffman· 1 shared C. Nash· 1 shared C. W. Dessauer· 1 shared D. Axelrod· 1 shared D. I. Yule· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPharmacology & Toxicology

W. Wei

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3 papers

Recent·Most cited

A PACAP-activated network for secretion requires coordination of calcium influx and calcium mobilization

X. Chen, N. A. Bell, B. L. Coffman, A. Rabino, R. Garcia-Mata, D. I. Yule, D. Axelrod, A. Smrcka, D. R. Giovannucci, A. Anantharam

The paper shows PACAP induces sustained Ca2+ increases in chromaffin cells by coupling Ca2+ influx and mobilization via PLCε activity.

bioRxiv · Jan 3, 2024Cell Biology

Stablization of Interdomain Interactions in G protein αi Subunits Determines Gαi Subtype Signaling Specificity

T. Lefevre, W. Wei, E. Mukhaleva, S. P. M. Venkata, N. R. Chandan, S. Abraham, Y. Li, C. W. Dessauer, N. Vaidehi, A. Smrcka

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.

bioRxiv · Mar 10, 2023Pharmacology & Toxicology

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

C. Nash, W. Wei, R. Irannejad, A. Smrcka

The paper identifies a pathway where Golgi localized β1-adrenergic receptors stimulate PI4P hydrolysis via PLCε to promote cardiac hypertrophy, distinct from surface receptor signaling.

bioRxiv · May 19, 2019Cell Biology