Cell density-dependent ferroptosis in breast cancer is induced by accumulation of polyunsaturated fatty acid-enriched triacylglycerides
E. Panzilius, F. Holstein, J. Dehairs, M. Planque, C. von Toerne, A.-C. Koenig, S. Doll, M. Bannier-Helaouët, H. M. Ganz, S. M. Hauck, A. Talebi, J. V. Swinnen, S.-M. Fendt, J. P. Friedmann Angeli, M. Conrad, C. H. Scheel
This study shows that low cell density in breast cancer cells increases ferroptosis sensitivity by promoting PUFA-enriched TAG accumulation and reducing lipid desaturation.
bioRxiv · Oct 1, 2019 · PreprintCancer Biology