M. Conrad

PRDX6 dictates ferroptosis sensitivity by directing cellular selenium mobilization

The paper shows PRDX6 influences ferroptosis sensitivity by managing cellular selenium levels, which affects GPX4 function.

Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis

This study shows ferroptosis occurs in kidney tubules of lupus nephritis patients and mice, and a drug can reduce it, suggesting new treatment options.

Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

NFE2L1-mediated proteasome function protects from ferroptosis

This study identifies NFE2L1 as a regulator of proteasome function that protects cells from ferroptosis, with implications for cancer and neurodegenerative diseases.

The crystal structure of the varicella zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity

The paper describes the crystal structure of the VZV Orf24-Orf27 complex, revealing subfamily-specific features that explain differences in NEC interactions across herpesviruses.

Mutations in the B.1.1.7 SARS-CoV-2 spike protein reduce receptor-binding affinity and induce a flexible link to the fusion peptide

This paper uses molecular dynamics simulations to show that B.1.1.7 SARS-CoV-2 mutations reduce ACE2 binding affinity and increase flexibility near the fusion peptide, potentially contributing to higher infectivity.

Cell density-dependent ferroptosis in breast cancer is induced by accumulation of polyunsaturated fatty acid-enriched triacylglycerides

This study shows that low cell density in breast cancer cells increases ferroptosis sensitivity by promoting PUFA-enriched TAG accumulation and reducing lipid desaturation.

Conjugated linolenic fatty acids trigger ferroptosis in triple-negative breast cancer

This study identifies conjugated linolenic acids as ferroptosis inducers in triple-negative breast cancer and shows their anti-tumor effects in a xenograft model.