J. Rabinowitz

One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade

This study shows that supplementing one-carbon units enhances anti-PD-1 checkpoint blockade by supporting purine synthesis in tumor-infiltrating T cells, leading to increased durable tumor regression.

Identification of novel role of sterol regulatory element binding proteins (SREBPs) in mechanotransduction and intraocular pressure regulation

This study identifies SREBPs as regulators of intraocular pressure by modulating TM biomechanics through lipogenesis and ECM dynamics.

Glycine homeostasis requires reverse SHMT flux

The paper shows that SHMT flux consumes glycine rather than producing it, with liver SHMT2 playing a major role in glycine consumption.

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

The paper identifies an antisense RNA, NQO1-AS, that promotes breast cancer metastasis by stabilizing NQO1 mRNA, enhancing oxidative stress tolerance and enabling lung colonization.

Serine catabolism generates NADPH to support hepatic lipogenesis

The paper shows that liver generates NADPH for lipogenesis through serine catabolism, distinct from adipose which uses glucose and the pentose phosphate pathway.

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

This study identifies MTHFD2 as a metabolic checkpoint that regulates T cell fate and function by promoting effector cells and suppressing regulatory T cells.

The Metabolites NADP+ and NADPH are the Targets of the Circadian Protein Nocturnin (Curled)

This study identifies NADP+ and NADPH as substrates of the circadian protein Nocturnin, showing its enzymatic activity in converting these metabolites and revealing structural insights into its mechanism.