Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response
D. G. Ryan, E. V. Knatko, A. Casey, J. L. Hukelmann, A. J. Brenes, S. Dayalan Naidu, M. Higgins, L. Tronci, E. Nikitopoulou, L. A. O'Neill, A. I. Lamond, A. Y. Abramov, D. A. Cantrell, M. P. Murphy, A. T. Dinkova-Kostova
This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.
bioRxiv · Aug 13, 2021 · PreprintImmunology