Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML
Gege Gui, Molly A. Bingham, Julius R. Herzog, Abigail Wong-Rolle, Laura Williams Dillon, Meghali Goswami, Eddie Martin, Jason Reeves, Sean T. Kim, Arya J. Bahrami, Hermann Franz Degenhardt, George Zaki, Prajan Divakar, Edward C. Schrom, Katherine R. Calvo, , Chen Ning Zhao
CosMx spatial transcriptomics of bone marrow from 6 refractory/relapsed AML patients shows CD14+ monocytes rising in leukemia-cell neighborhoods after pembrolizumab in responders, dendritic cells in nonresponders.
Science Advances · Jul 9, 2025Peer-reviewedCancer Biology✦ In-depth digest