Laura Williams Dillon

CosMx spatial transcriptomics of bone marrow from 6 refractory/relapsed AML patients shows CD14+ monocytes rising in leukemia-cell neighborhoods after pembrolizumab in responders, dendritic cells in nonresponders.

This paper benchmarks HLA genotype prediction from single-cell RNA-seq data against molecular genotyping, showing improved accuracy with composite models and meta-analytic approaches.

The paper shows that microDNA produces regulatory RNAs that suppress gene expression through miRNA and si-like RNA mechanisms.