Author

Abigail Wong-Rolle

National Cancer InstituteORCID 0000-0002-3249-9323Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Chen Ning ZhaoiD· 2 shared Edward C. SchromiD· 2 shared Arya J. Bahrami· 1 shared Chengcheng JiniD· 1 shared Christopher Simon HouriganiD· 1 shared Eddie Martin· 1 shared Gege GuiiD· 1 shared George ZakiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersImmunology

Chen Ning ZhaoORCID

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2 papers

Recent·Most cited

PD-1 controls differentiation, survival, and TCR affinity evolution of stem-like CD8+ T cells

Jyh Liang Hor, Edward C. Schrom, Abigail Wong-Rolle, Luke F. Vistain, Wanjing Shang, Qiang Dong, Chen Ning Zhao, Chengcheng Jin, Ronald N. Germain

This study identifies PD-1's role in maintaining stem-like CD8+ T cells through TCR affinity regulation and signaling fine-tuning, showing its impact on immunotherapy efficacy.

Nature · Nov 26, 2025Peer-reviewedImmunology

Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML

Gege Gui, Molly A. Bingham, Julius R. Herzog, Abigail Wong-Rolle, Laura Williams Dillon, Meghali Goswami, Eddie Martin, Jason Reeves, Sean T. Kim, Arya J. Bahrami, Hermann Franz Degenhardt, George Zaki, Prajan Divakar, Edward C. Schrom, Katherine R. Calvo, , Chen Ning Zhao

CosMx spatial transcriptomics of bone marrow from 6 refractory/relapsed AML patients shows CD14+ monocytes rising in leukemia-cell neighborhoods after pembrolizumab in responders, dendritic cells in nonresponders.

Science Advances · Jul 9, 2025Peer-reviewedCancer Biology✦ In-depth digest