Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology
Amy M. Smith, Karen Davey, Stergios Tsartsalis, Combiz Khozoie, Nurun Nahar Fancy, See Swee Tang, Eirini Liaptsi, Maria Weinert, Aisling McGarry, Robert C. J. Muirhead, Steve Gentleman, David R. Owen, Paul McMahan Matthews
This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.
Acta Neuropathologica · Nov 12, 2021Peer-reviewedNeuroscience