Author

Robert C. J. Muirhead

UK Dementia Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:scRNA-seq· 2 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Amy M. SmithiD· 3 shared David R. OweniD· 3 shared Nurun Nahar FancyiD· 3 shared Paul McMahan MatthewsiD· 3 shared Stergios TsartsalisiD· 3 shared Aisling McGarryiD· 2 shared Combiz KhozoieiD· 2 shared Karen Davey· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Amy M. SmithORCID

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Author profile →

3 papers

Recent·Most cited

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer's disease

Stergios Tsartsalis, Hannah Sleven, Nurun Nahar Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal Rokicki, Vicky M. N. Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, , Paul McMahan Matthews

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

Nature Communications · Mar 12, 2024Peer-reviewedNeuroscience

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

Erik Nutma, Nurun Nahar Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene N. Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper J. Anink, David Story, Siddharthan Chandran, Jiabin Tang, , David R. Owen

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

Nature Communications · Aug 28, 2023Peer-reviewedNeuroscience

Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology

Amy M. Smith, Karen Davey, Stergios Tsartsalis, Combiz Khozoie, Nurun Nahar Fancy, See Swee Tang, Eirini Liaptsi, Maria Weinert, Aisling McGarry, Robert C. J. Muirhead, Steve Gentleman, David R. Owen, Paul McMahan Matthews

This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.

Acta Neuropathologica · Nov 12, 2021Peer-reviewedNeuroscience