Combiz Khozoie

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.

scFlow provides a scalable, reproducible pipeline for analyzing single-cell RNA-seq data, demonstrating its utility with public datasets and extensibility as an open-source tool.