Author

Ekaterina Pyatova

SIB Swiss Institute of Bioinformatics

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Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:multiple species· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Adrie H. WestphaliD· 1 shared Alex J. VecchioiD· 1 shared Ana Alcaraz‐SernaiD· 1 shared Andrew M. WollacottiD· 1 shared Bernard Laurent SchneideriD· 1 shared Brahm J. YachniniD· 1 shared Bruno E. CorreiaiD· 1 shared Casper A. GoverdeiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Adrie H. WestphalORCID

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1 paper

Recent·Most cited

BindCraft: one-shot design of functional protein binders

Martin Pačesa, Lennart Nickel, Christian Schellhaas, Joseph H. Schmidt, Ekaterina Pyatova, Lucas Kissling, Patrick Barendse, Jagrity Choudhury, Srajan Kapoor, Ana Alcaraz‐Serna, Yehlin Cho, Kourosh H. Ghamary, Laura Vinué, Brahm J. Yachnin, Andrew M. Wollacott, , Bruno E. Correia

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

bioRxiv · Sep 30, 2024 · PreprintBioinformatics✦ In-depth digest