Melanie Klose

Bottom-up reconstruction of minimal pyrenoids provides insights into the evolution and mechanisms of carbon concentration by EPYC1 proteins

The paper reconstructs minimal pyrenoids using EPYC1 proteins to study their evolution and carbon concentration mechanisms.

Combining evolution and machine learning-guided pathway optimization to engineer a novel methylsuccinate module for synthetic C1 metabolism in vivo

This paper combines adaptive laboratory evolution and machine learning to engineer a methylsuccinate module for synthetic C1 metabolism in E. coli, achieving growth in three weeks versus six months with evolution alone.

Advancing chloroplast synthetic biology through high-throughput plastome engineering of Chlamydomonas reinhardtii

This study establishes Chlamydomonas reinhardtii as a platform for chloroplast synthetic biology, enabling high-throughput engineering of plastomes and demonstrating improved biomass production through synthetic pathways.