Activation of PP2A-B56α leads to aberrant EGFR signaling and proliferative phenotypes in PDAC
Claire M. Pfeffer, Sydney J. Clifford, Saadia A. Karim, Ella Rose D. Chianis, Brittany N. Heil, Lauren E. Gartenhaus, Emma F. Kay, Garima Baral, Elizabeth G. Hoffman, Sagar M. Utturkar, Harish Kothandaraman, Whitney R. Smith-Kinnaman, Kasi Hansen, Emily G. Smith, Elisabeth Porter, , Brittany L. Allen-Petersen
This study shows that activating PP2A-B56 in PDAC increases EGFR signaling and promotes tumor growth, suggesting a new therapeutic target.
bioRxiv · Jul 18, 2025 · PreprintCancer Biology