The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
Sarah J. Shemtov, Eric G. McGann, Lucy Carrillo, Sangmin Lee, Herbert Anson, Eric Hwang, Claire S Chung, Jaye L. Weinert, Maria‐Eleni Anagnostou, Guan-Ju Lai, Bert M. Verheijen, Junxiang Wan, Ivetta Vorobyova, Mónica Sánchez-Contreras, Cheryl A. Conover, , Marc Vermulst
This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.
Science Advances · Apr 3, 2026Peer-reviewedMolecular Biology