Ivetta Vorobyova

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

Tcf12 controls dynamic calvarial bone growth and motor learning in mice

This study investigates the role of Tcf12 in calvarial bone development and motor learning in mice, finding that Tcf12 loss leads to altered bone formation and impaired motor learning.