Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors
Masaaki Yoshigi, Séverin Donald Kamdem, Hanghang Wang, Amav Khambete, Francis Sprouse, Ernest M. Kameni, Estelle Atiogue, Sarah Pellizzari, Kimberley Jane Evason, My N. Helms, Michael A. Goodman, Shuang Wang, Jisun So, Hyun Cheol Roh, Sihem Boudina, , Patrice Nsangou Mimche
This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.
bioRxiv · Nov 19, 2025 · PreprintPathology