Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism
KayLee K. Steiner, Arissa Young, Andrew R. Patterson, Ayaka Sugiura, McLane J. Watson, Samuel E.J. Preston, A. R. Zhelonkin, Erin Q. Jennings, Channing Chi, Darren R. Heintzman, Andrew P Pahnke, Yasmine T. Toudji, Zaid Hatem, Matthew Z. Madden, Emily Nicole Arner, , Jeffrey C. Rathmell
This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.
The Journal of Immunology · Apr 9, 2025Peer-reviewedImmunology