Author

McLane J. Watson

Van Andel InstituteORCID 0000-0001-5778-7690Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Russell G. JonesiD· 2 shared Ryan D. SheldoniD· 2 shared Samuel E.J. PrestoniD· 2 shared A. R. ZhelonkiniD· 1 shared Abigail E. EllisiD· 1 shared Allison E. SewelliD· 1 shared Allison K Blount· 1 shared Andrew P PahnkeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Russell G. JonesORCID

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2 papers

Recent·Most cited

Dietary Restriction Enhances CD8+ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity

Brandon M. Oswald, Lisa M. DeCamp, Joseph Longo, Michael S. Dahabieh, Nicholas Bunda, Benjamin K. Johnson, McLane J. Watson, Shixin Ma, Samuel E.J. Preston, Ryan D. Sheldon, Michael P. Vincent, Abigail E. Ellis, Molly T. Soper-Hopper, Christine N. Isaguirre, Dahlya Kamarudin, , Russell G. Jones

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

Nature Metabolism · Dec 9, 2025Peer-reviewedImmunology

Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism

KayLee K. Steiner, Arissa Young, Andrew R. Patterson, Ayaka Sugiura, McLane J. Watson, Samuel E.J. Preston, A. R. Zhelonkin, Erin Q. Jennings, Channing Chi, Darren R. Heintzman, Andrew P Pahnke, Yasmine T. Toudji, Zaid Hatem, Matthew Z. Madden, Emily Nicole Arner, , Jeffrey C. Rathmell

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

The Journal of Immunology · Apr 9, 2025Peer-reviewedImmunology