M. Cosentino Lagomarsino

The paper shows that metacommunities can maintain genome diversity despite gene-specific selective sweeps through mathematical modeling and simulations.

The paper develops a fitness model to explain the trade-offs in yeast aneuploids, showing how chromosome gains can be beneficial under stress but costly otherwise.

The paper measures cytoplasmic and nuclear volumes in human cells and finds cytoplasm grows exponentially while nucleus grows linearly, showing cytoskeletal forces influence nuclear import and volumetric coupling via osmosis.

The paper examines nuclear shape fluctuations during the cell cycle and finds they correlate with chromatin condensation and nuclear-envelope breakdown in mitosis.

The paper evolves yeast populations with impaired microtubule polymerization and identifies mutations and chromosome duplications that confer resistance to microtubule depolymerizing drugs.

The paper develops an evolutionary model to identify selective pressures shaping genome-replication profiles in yeast by analyzing replication origin dynamics.

The paper investigates E. coli cell division behavior during nutrient upshifts and finds that a constitutive protein accumulates to a threshold, triggering division and maintaining adder correlations.

This study shows ppGpp regulates bacterial cell size by controlling growth rate and division, leading to size homeostasis.

The paper quantifies how translation inhibition reduces transcription capacity by limiting free RNA polymerase availability, affecting gene expression based on mRNA length.

This study re-evaluates existing models of DNA replication and cell division in E. coli, concluding that replication is not the sole bottleneck and proposing a dual-cycle mechanism.

The paper challenges the classic view that chromosome segregation limits cell division in E. coli, showing instead that two concurrent processes set division on competing time scales.