D. Vorselen

Size-Dependent Mechanoadaptation Enables Migration with Oversized Parasitic Cargo

The paper investigates how cells adapt to transport oversized parasitic cargo by reprogramming mechanical forces and subcellular architecture during migration.

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

Single-Cell Stress Analysis in Tumoroids.

This paper introduces a method to measure cellular traction forces in 3D tumoroid cultures using elastic microparticles, revealing cellular stress ranges and interactions with the extracellular matrix.

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

Cell surface receptors TREM2, CD14 and integrin αMβ2 drive sinking engulfment in phosphatidylserine-mediated phagocytosis

This study identifies TREM2, CD14, and integrin αMβ2 as essential cell surface receptors for PS-mediated phagocytosis, revealing distinct mechanisms for PS and antibody-coated target uptake.

Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis

The paper measures cytoplasmic and nuclear volumes in human cells and finds cytoplasm grows exponentially while nucleus grows linearly, showing cytoskeletal forces influence nuclear import and volumetric coupling via osmosis.

Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis

The paper uses microscopy and force measurement techniques to show how localized actin and myosin forces drive target constriction during phagocytosis, revealing a distinct mechanism from 2D cell motility.

Superresolved microparticle traction force microscopy reveals subcellular force patterns in immune cell-target interactions

This paper develops a superresolution traction force microscopy method to measure subcellular forces in immune cell-target interactions without using embedded tracers.

The fluid membrane determines mechanics of red blood cell extracellular vesicles and is softened in hereditary spherocytosis

This study uses atomic force microscopy to analyze the mechanical properties of red blood cell extracellular vesicles from healthy individuals and a hereditary spherocytosis patient, finding that vesicles have a lower bending modulus in the disease state.