Author

M. De Leon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. J. Dowling· 3 shared E. Nanishi· 3 shared O. Levy· 3 shared A. Ozonoff· 2 shared B. Brook· 2 shared D. Soni· 2 shared F. Borriello· 2 shared K. Chew· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

D. J. Dowling

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Author profile →

4 papers

Recent·Most cited

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

K. Chew, B. Lee, S. Van Haren, E. Nanishi, T. R. O'Meara, J. B. Splaine, M. De Leon, D. Soni, H.-S. R. Seo, S. Dhe-Paganon, A. Ozonoff, J. A. Smith, O. Levy, D. J. Dowling

This paper describes a high-throughput screening method using human PBMCs to identify adjuvant candidates, resulting in a lead compound with in vivo adjuvanticity.

bioRxiv · Jun 17, 2022 · PreprintImmunology

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

S. Barman, F. Borriello, B. Brook, C. Pietrasanta, M. De Leon, C. Sweitzer, M. Menon, S. D. van Haren, D. Soni, Y. Saito, E. Nanishi, S. Yi, S. Bobbala, O. Levy, E. A. Scott, D. J. Dowling

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

bioRxiv · Jun 3, 2022Immunology

Gut Microbiome Signatures Linked to HIV-1 Reservoir Size and Viremia Control

A. Borgognone, M. Noguera-Julian, B. Oriol, L. Noël-Romas, M. Ruiz-Riol, Y. Guillen, M. Parera, M. Casadella, C. Duran, M. C. Puertas, F. Catala-Moll, M. De Leon, S. Knodel, K. Birse, C. Manzardo, , R. Paredes

The paper identifies gut microbiome signatures, specifically the Bacteroidales/Clostridiales ratio, associated with HIV-1 reservoir size and viremia control in a clinical trial.

bioRxiv · Oct 3, 2021Immunology

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology