Cell BiologybioRxivPreprint
Conformational dynamics regulate SHANK3 actin and Rap1 binding
S. I. Salomaa, M. Miihkinen, E. Kremneva…·J. Ivaska
This study shows SHANK3 binds actin and Rap1 through its SPN domain, with conformational changes regulating this interaction and affecting cellular processes like filopodia formation and autism-related phenotypes.
DOI 10.1101/2020.11.12.379222