J. Ivaska

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.

Specialized actin nanoscale layers control focal adhesion turnover

The paper identifies two new nanoscale actin layers in focal adhesions, showing their distinct roles in adhesion maturation and disassembly through Tpm1.6 and Tpm3.2.

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

This study identifies SHANK3 as a RAS interactor that limits oncogenic KRAS signaling, and shows that disrupting its interaction with KRAS induces cell death in KRAS-mutant cancers.

Myosin-X recruits lamellipodin to filopodia tips

The paper identifies lamellipodin as a novel cargo of myosin-X and shows it is transported to filopodia tips to support their formation and stability.

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers

This study identifies PME-1 as a biomarker for aggressive PTEN-deficient prostate cancers by showing its role in suppressing anoikis.

AXL-TBK1 driven nuclear AKT3 promotes metastasis

This study identifies AXL-TBK1-driven nuclear AKT3 as a driver of EMT and metastasis, showing that selective AKT3 inhibition reduces tumor progression in breast cancer.

Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries

This study shows MYO10 promotes BM assembly in DCIS to limit invasion but facilitates cancer cell dissemination in invasive breast cancer.

Sortilin-related receptor is a druggable therapeutic target in breast cancer

This study shows that targeting SorLA with a monoclonal antibody can overcome HER2 resistance in breast cancer, both in vitro and in vivo.

Conformational dynamics regulate SHANK3 actin and Rap1 binding

This study shows SHANK3 binds actin and Rap1 through its SPN domain, with conformational changes regulating this interaction and affecting cellular processes like filopodia formation and autism-related phenotypes.

Negative durotaxis: cell movement toward softer environments

The paper identifies negative durotaxis, where cells migrate toward softer environments, and shows that integrin adhesion and motor-clutch dynamics drive this behavior in glioblastoma and neurites.

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis

The paper identifies swiprosin-1 as a cargo-specific adaptor for the CG-pathway, showing its role in integrin internalization and breast cancer progression.

A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance

This study identifies a feed-forward loop involving SorLA and HER3 that enhances heregulin response and neratinib resistance in breast cancer.

Talin Rod Domain Containing Protein 1 (TLNRD1) is a novel actin- bundling protein which promotes filopodia formation

This study identifies TLNRD1 as an actin-bundling protein that promotes filopodia formation and cell migration by interacting with LD-motif proteins like RIAM and KANK.

Myosin-X and talin modulate integrin activity at filopodia tips

The paper identifies MYO10 and talin as key regulators of integrin activity in filopodia, proposing a two-step model for integrin activation.

Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity

This study shows that laminin alpha 5 is essential for mammary gland growth and function by maintaining luminal epithelial cell identity during development and remodeling.

Integrin binding dynamics modulate ligand-specific mechanosensing in mammary gland fibroblasts

This study shows that SHARPIN regulates collagen-specific mechanosensing in mammary fibroblasts by modulating integrin 11β1 activity and force transmission.

Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels

This study investigates how fibrillar adhesions respond to mechanical cues by using stiffness-gradient gels and identifies tensin-dependent growth of these structures in response to stiffness.

Fluctuation-based Super-Resolution Traction Force Microscopy

This paper introduces a method to improve traction force microscopy resolution and throughput using super-resolution microscopy based on fluorophore fluctuation analysis.

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

This study identifies GGA2 and RAB13 as regulators of activity-dependent β1-integrin recycling, showing their roles in maintaining integrin activity and cell migration.

Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability

The paper maps filopodia adhesions using structured illumination microscopy and identifies p130Cas as a mechanosensitive regulator of filopodia stability.

SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2

This study shows SORLA regulates HER2 trafficking, affecting its oncogenic activity and response to therapy.

FiloQuant reveals increased filopodia density during DCIS progression

FiloQuant quantifies filopodia density and dynamics in various cell types and microenvironments, revealing increased filopodia density during DCIS progression.