Author

A. Isomursu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Ivaska· 5 shared I. Paatero· 3 shared C. Guzman· 2 shared G. Jacquemet· 2 shared M. Georgiadou· 2 shared A. Aakula· 1 shared A. Erickson· 1 shared A. Kaur· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersCell Biology

J. Ivaska

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers

A. Aakula, A. Isomursu, C. Rupp, A. Erickson, O. Kauko, P. Shah, A. Padzik, Y. R. Pokharel, A. Kaur, S.-P. Li, L. Trottman, P. Taimen, A. Rannikko, J. Lammerding, I. Paatero, , J. Westermarck

This study identifies PME-1 as a biomarker for aggressive PTEN-deficient prostate cancers by showing its role in suppressing anoikis.

bioRxiv · Mar 17, 2022 · PreprintCancer Biology

Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries

E. Peuhu, G. Jacquemet, C. L. Scheele, A. Isomursu, I. Paatero, K. Thol, M. Georgiadou, C. Guzman, S. Koskinen, A. Laiho, L. L. Elo, P. Boström, P. Hartiala, J. van Rheenen, J. Ivaska

This study shows MYO10 promotes BM assembly in DCIS to limit invasion but facilitates cancer cell dissemination in invasive breast cancer.

bioRxiv · Oct 22, 2021 · PreprintCell Biology

Conformational dynamics regulate SHANK3 actin and Rap1 binding

S. I. Salomaa, M. Miihkinen, E. Kremneva, I. Paatero, J. Lilja, G. Jacquemet, J. Vuorio, L. Antenucci, F. Hassani-Nia, P. Hollos, A. Isomursu, I. Vattulainen, E. T. Coffey, H.-J. Kreienkamp, P. Lappalainen, J. Ivaska

This study shows SHANK3 binds actin and Rap1 through its SPN domain, with conformational changes regulating this interaction and affecting cellular processes like filopodia formation and autism-related phenotypes.

bioRxiv · Nov 12, 2020 · PreprintCell Biology

Negative durotaxis: cell movement toward softer environments

A. Isomursu, K.-Y. Park, J. Hou, C. Bo, G. Shamsan, B. Fuller, J. Kasim, M. M. Mahmoodi, T. J. Lu, G. M. Genin, F. Xu, M. Lin, M. Distefano, J. Ivaska, D. J. Odde

The paper identifies negative durotaxis, where cells migrate toward softer environments, and shows that integrin adhesion and motor-clutch dynamics drive this behavior in glioblastoma and neurites.

bioRxiv · Oct 27, 2020 · PreprintBiophysics

Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels

N. Barber-Perez, M. Georgiadou, C. Guzman, A. Isomursu, H. Hamidi, J. Ivaska

This study investigates how fibrillar adhesions respond to mechanical cues by using stiffness-gradient gels and identifies tensin-dependent growth of these structures in response to stiffness.

bioRxiv · Dec 12, 2019Cell Biology