Author

I. Paatero

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8 Cancer Biology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 7 Assay:proteomics· 7 Research Focus:cell signaling & trafficking· 6 Research Focus:cell type annotation· 5 Organism:zebrafish· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

J. Ivaska· 8 shared A. Padzik· 5 shared G. Jacquemet· 4 shared A. Isomursu· 3 shared K. Elenius· 3 shared P. Taimen· 3 shared A. Jokilammi· 2 shared E. Peuhu· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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8 shared papersCell Biology

J. Ivaska

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Author profile →

12 papers

Recent·Most cited

JNK1 And Downstream Signalling Hubs Regulate Anxiety-Like Behaviours In A Zebrafish Larvae Phenotypic Screen

Y. Hong, C. Sourander, B. Hackl, J. Patton, J. John, I. Paatero, E. Coffey

The paper identifies JNK1 downstream signalling hubs that regulate anxiety-like behaviours in zebrafish larvae using a behavioural assay and phosphoproteome analysis.

Scientific Reports · May 15, 2024Peer-reviewedPharmacology & Toxicology

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB inhibitor-induced phenotypes

K. M. Vaparanta, A. Jokilammi, J. Merilahti, J. Orling, N. Virtanen, C. Sahlgren, K. Elenius, I. Paatero

This study uses phosphoproteomic analysis in zebrafish to show that ErbB inhibitors affect multiple signaling pathways, leading to similar physiological phenotypes.

bioRxiv · Mar 12, 2024Cell Biology

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

N. J. Ball, S. Ghimire, G. Follain, A. O. Pajari, M. Vaitkeviciute, A. R. Cowell, B. Berki, J. Ivaska, I. Paatero, B. T. Goult, G. Jacquemet

This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.

bioRxiv · Sep 29, 2023Cell Biology

Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis

M. Momeny, M. Tienhaara, D. Chakroborty, M. Sharma, R. Varjus, J. Merisaari, A. Padzik, A. Vogt, I. Paatero, K. Kurppa, K. Elenius, T. D. Laajala, J. Westermarck

This study identifies DUSP6 as a driver of HER2 inhibitor tolerance through the Neuregulin/HER3 axis by analyzing the transcriptional changes during the DTP-DTEP transition in HER2+ breast cancer cells.

bioRxiv · Jun 14, 2023 · PreprintCancer Biology

STAT5b is a key effector of NRG-1/ERBB4-mediated cardiomyocyte growth

K. M. Vaparanta, A. Jokilammi, I. Paatero, J. A. M. Merilahti, J. Heliste, K. A. Hemanthakumar, R. Kivelä, K. K. Alitalo, P. Taimen, K. Elenius

This study identifies STAT5b as a critical mediator of NRG-1/ERBB4-induced cardiomyocyte growth and shows its dysregulation in cardiac hypertrophy.

bioRxiv · Oct 5, 2022 · PreprintCell Biology

PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers

A. Aakula, A. Isomursu, C. Rupp, A. Erickson, O. Kauko, P. Shah, A. Padzik, Y. R. Pokharel, A. Kaur, S.-P. Li, L. Trottman, P. Taimen, A. Rannikko, J. Lammerding, I. Paatero, , J. Westermarck

This study identifies PME-1 as a biomarker for aggressive PTEN-deficient prostate cancers by showing its role in suppressing anoikis.

bioRxiv · Mar 17, 2022 · PreprintCancer Biology

Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries

E. Peuhu, G. Jacquemet, C. L. Scheele, A. Isomursu, I. Paatero, K. Thol, M. Georgiadou, C. Guzman, S. Koskinen, A. Laiho, L. L. Elo, P. Boström, P. Hartiala, J. van Rheenen, J. Ivaska

This study shows MYO10 promotes BM assembly in DCIS to limit invasion but facilitates cancer cell dissemination in invasive breast cancer.

bioRxiv · Oct 22, 2021 · PreprintCell Biology

Conformational dynamics regulate SHANK3 actin and Rap1 binding

S. I. Salomaa, M. Miihkinen, E. Kremneva, I. Paatero, J. Lilja, G. Jacquemet, J. Vuorio, L. Antenucci, F. Hassani-Nia, P. Hollos, A. Isomursu, I. Vattulainen, E. T. Coffey, H.-J. Kreienkamp, P. Lappalainen, J. Ivaska

This study shows SHANK3 binds actin and Rap1 through its SPN domain, with conformational changes regulating this interaction and affecting cellular processes like filopodia formation and autism-related phenotypes.

bioRxiv · Nov 12, 2020 · PreprintCell Biology

A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance

H. Al-Akhrass, J. R. W. Conway, A. S. A. Poulsen, I. Paatero, J. Kaivola, A. Padzik, O. M. Andersen, J. Ivaska

This study identifies a feed-forward loop involving SorLA and HER3 that enhances heregulin response and neratinib resistance in breast cancer.

bioRxiv · Jun 10, 2020Cancer Biology

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

P. Sahgal, J. Alanko, J. Icha, I. Paatero, H. Hamidi, A. Arjonen, M. Pietila, A. Rokka, J. Ivaska

This study identifies GGA2 and RAB13 as regulators of activity-dependent β1-integrin recycling, showing their roles in maintaining integrin activity and cell migration.

bioRxiv · Feb 25, 2019Cell Biology

SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2

M. Pietila, P. Sahgal, E. Peuhu, N. Jantti, I. Paatero, O. M. Andersen, A. Padzik, M. Blomqvist, I. Saarinen, P. Bostrom, P. Taimen, J. Ivaska

This study shows SORLA regulates HER2 trafficking, affecting its oncogenic activity and response to therapy.

bioRxiv · Apr 11, 2018Cell Biology

FiloQuant reveals increased filopodia density during DCIS progression

G. Jacquemet, I. Paatero, A. Carisey, A. Padzik, J. Orange, H. Hamidi, J. Ivaska

FiloQuant quantifies filopodia density and dynamics in various cell types and microenvironments, revealing increased filopodia density during DCIS progression.

bioRxiv · Apr 6, 2017Cell Biology