Author

H. N. Higgs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

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Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Liu· 1 shared A. Y. Shih· 1 shared B. Calabrese· 1 shared C. J. Latario· 1 shared C. L. Howarth· 1 shared D. A. Fischer· 1 shared F. Begum· 1 shared F. Kage· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCell Biology

A. Liu

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4 papers

Recent·Most cited

Long-chain fatty acyl-coenzyme A activates the mitochondrial fission factors MiD49 and MiD51 by inducing their oligomerization

A. Liu, F. Kage, G. Sapp, H. Aydin, H. N. Higgs

This study shows that long-chain fatty acyl-CoA activates mitochondrial fission proteins MiD49 and MiD51 by inducing their oligomerization, which enhances DRP1 GTPase activity and promotes mitochondrial fission.

bioRxiv · Jul 31, 2023 · PreprintCell Biology

INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury

B. Calabrese, S. Jones, Y. Yamaguchi-Shiraishi, M. J. Lingelbach, U. Manor, T. M. Svitkina, H. N. Higgs, A. Y. Shih, S. Halpain

This study shows that INF2-mediated actin reorganization in neurons protects against ischemic injury by counteracting swelling-induced cell death.

bioRxiv · Oct 1, 2021Cell Biology

Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner

C. J. Latario, L. W. Schoenfeld, C. L. Howarth, L. E. Pickrell, F. Begum, D. A. Fischer, O. Grbovic-Huezo, S. D. Leach, Y. Sanchez, K. D. Smith, H. N. Higgs

This study identifies tumor microtubes (TMTs) in pancreatic cancer cells, showing they depend on the Arp2/3 complex for assembly and differ structurally from tunneling nanotubes.

bioRxiv · Nov 14, 2019Cell Biology

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum

W.-K. Ji, R. Chakrabarti, X. Fan, L. Schoenfeld, S. Strack, H. N. Higgs

This paper identifies ER-associated Drp1 oligomers formed via Mff and shows their role in mitochondrial division.

bioRxiv · Sep 18, 2017Cell Biology