F. Radvanyi

Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies.

The paper develops patient-derived xenografts (PDXs) for bladder and ureteral cancers, identifies molecular subtypes, and shows that combined FGFR/EGFR inhibition is more effective than single-agent therapy for FGFR3-mutant tumors.

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks

The paper identifies super-enhancer networks regulating bladder cancer subtypes through transcription factors, showing their role in cell identity and inflammatory response suppression.

FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias.

This study shows FGFR3-S249C mutations drive luminal-like papillary bladder tumors in mice and correlate with male gender bias and AR activity in human tumors.

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells

This study investigates how STAG2 loss-of-function affects genomic contacts and urothelial differentiation in bladder cancer cells, finding that STAG2 is critical for DNA looping that sustains luminal differentiation.

Transcription Factor EB regulates phosphatidylinositol-3-phosphate levels on endomembranes and alters lysosome positioning in the bladder cancer model

This study identifies TFEB's role in regulating PtdIns3P levels and lysosome positioning in bladder cancer, suggesting it as a potential biomarker and therapeutic target.

PPARG is a tumor suppressor in basal bladder tumors offering new potential therapeutic opportunities.

The paper identifies PPARγ as a tumor suppressor in basal bladder tumors and suggests therapeutic opportunities through PPARγ activation.

Role of a kinesin motor in cancer cell mechanics

This study investigates the role of KIF20A, a kinesin motor protein, in bladder cancer cell mechanics and motility, showing that its inhibition alters intracellular and cortical stiffness.

A consensus molecular classification of muscle-invasive bladder cancer

The paper identifies six consensus molecular classes of muscle-invasive bladder cancer using transcriptomic data and classification systems, providing a framework for future biomarker validation.