Author

P. A. Janmey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 3 Physiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. G. Wells· 6 shared V. B. Shenoy· 3 shared A. E. Loneker· 2 shared A. E. Patteson· 2 shared D. Chen· 2 shared D. Li· 2 shared E. Ban· 2 shared K. Mandal· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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6 shared papersCell Biology

R. G. Wells

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1

F. Byfield, B. Eftekhari, K. Kaymak-Loveless, K. Mandal, D. Li, R. G. Wells, W. Chen, J. Brujic, G. Bergamasschi, G. G. wuite, A. E. Patteson, P. A. Janmey

This study shows that BRG1 activity fluidizes the nucleus, altering its stiffness and dissipating mechanical energy, with implications for nuclear mechanics and remodeling.

bioRxiv · Apr 12, 2024Cell Biology

Lipid droplets are intracellular mechanical stressors that promote hepatocyte dedifferentiation

A. E. Loneker, F. Alisafaei, A. Kant, P. A. Janmey, V. B. Shenoy, R. G. Wells

This study shows lipid droplets act as intracellular mechanical stressors that cause nuclear deformation and hepatocyte dedifferentiation, similar to tissue stiffening effects.

bioRxiv · Aug 27, 2022 · PreprintCell Biology

Local fat content determines global and local stiffness in livers with simple steatosis

D. Li, P. A. Janmey, R. G. Wells

The paper examines how fat accumulation in livers with simple steatosis affects liver stiffness, finding that fat softens the liver locally rather than uniformly.

bioRxiv · Jul 14, 2022Physiology

Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices

D. Chen, Y. Du, J. Llewellyn, A. Bonna, B. Zuo, P. A. Janmey, R. W. Farndale, R. G. Wells

This study identifies versican as a collagen-binding protein that regulates collagen matrix organization and mechanics through its G3 domain.

bioRxiv · Mar 27, 2022Cell Biology

Glycosaminoglycans Modulate Long-Range Mechanical Communication Between Cells in Collagen Networks

X. Chen, D. Chen, E. Ban, P. A. Janmey, R. G. Wells, V. B. Shenoy

This paper shows that glycosaminoglycans (GAGs) reduce long-range mechanical communication between cells in collagen networks by preventing collagen fiber alignment.

bioRxiv · Sep 13, 2021Biophysics

Programmable and Contractile Materials Through Cell Encapsulation in Fibrous Hydrogel Assemblies

M. D. Davidson, M. E. Prendergast, E. Ban, K. L. Xu, G. Mickel, P. Mensah, A. Dhand, P. A. Janmey, V. B. Shenoy, J. A. Burdick

This paper develops fibrous hydrogel assemblies that contract when encapsulated with mesenchymal stromal cells, enabling programmed shape changes for biofabrication and tissue engineering.

bioRxiv · Apr 19, 2021Bioengineering

Extracellular vimentin as a target against SARS- CoV-2 host cell invasion

L. Suprewicz, M. Swoger, S. Gupta, E. Piktel, F. F. Byfield, D. V. Iwamoto, D. A. Germann, J. Reszec, N. Marcinczyk, R. Carroll, M. Lenart, K. Pyrc, P. A. Janmey, J. M. Schwarz, R. Bucki, A. E. Patteson

The paper identifies extracellular vimentin as a potential target for preventing SARS-CoV-2 infection by showing it facilitates viral entry through interaction with the spike protein and ACE2.

bioRxiv · Jan 8, 2021Biophysics

Lipid droplets disrupt mechanosensing in human hepatocytes

L. Chin, N. D. Theise, A. E. Loneker, P. A. Janmey, R. G. Wells

This study shows that lipid droplets in hepatocytes disrupt mechanosensing by altering YAP nuclear localization and affecting cell spreading and focal adhesions.

bioRxiv · Mar 31, 2020Physiology

Role of a kinesin motor in cancer cell mechanics

K. Mandal, K. Pogoda, S. Nandi, S. Mathieu, A. Kasri, F. Radvanyi, B. Goud, P. A. Janmey, J.-B. Manneville

This study investigates the role of KIF20A, a kinesin motor protein, in bladder cancer cell mechanics and motility, showing that its inhibition alters intracellular and cortical stiffness.

bioRxiv · Jul 30, 2019Biophysics